Extracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes
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چکیده
منابع مشابه
Erythropoietin activates nitric oxide synthase in murine erythrocytes.
Erythropoietin (Epo) is the main regulator of erythrocyte production and a potent cytoprotective factor. It was suggested that some of Epo cytoprotective properties are due to its regulation of nitric oxide (NO) production. Recently, functionally active endothelial type NO synthase (eNOS) was discovered in mature murine and human red blood cells (RBC-eNOS). The goal of the present study was to ...
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Nitric oxide (NO) is highly reactive, produced in endothelial cells by endothelial NO synthase (eNOS) and has been implicated in sickle cell pathophysiology. We evaluated the distribution of functionally significant eNOS variants (the T786C variant in the promoter region, the Glu298Asp variant in exon 7, and the variable number of tandem repeats (VNTR) in intron 4) in Africans, African American...
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Background: This is a case-control study to determine the relationship between endothelial nitric oxide synthase (eNOS) gene -786T/C polymorphism in women with unexplaiend recurrent abortion in comparison with healty women.Materials and Methods: 95 women with history of at least 2 unexplaiend recurrent abortion in the reproductive age range 20-35 years as patients group and 95 healty women (age...
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reason that Schoenwaelder and Jackson did not observe an increase in cytosolic free calcium at higher concentrations of ABT-263 is unclear but may well relate to differences such as higher platelet density (3 108 cells/mL used by them compared with the lower cell density 5 107 cells/mL used in our study).3 In this regard we have previously reported that the efficacy of both ABT-263 (Navitoclax)...
متن کاملNitric oxide An ally in extracorporeal circulation?
Melki, V. 2016. Nitric oxide. An ally in extracorporeal circulation? Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1238. 81 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9626-5. Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed ...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2007
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.21.6.a1230